Thermo Fisher Scientific ARNT Monoclonal Antibody (OTI1F4), TrueMAB
ARNT 단백질을 인식하는 Mouse monoclonal antibody로, WB, IHC(P), ICC/IF에 적합합니다. Human 시료에 반응하며, Lyophilized 형태로 제공됩니다. TrueMAB 형식으로 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F4 |
| Immunogen | Full length human recombinant protein of human ARNT produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
HIF-1 beta (ARNT) is an aryl hydrocarbon receptor nuclear translocator involved in mammalian oxygen homeostasis.
HIF-1 is a heterodimer composed of HIF-1 alpha and HIF-1 beta subunits. Under normoxic conditions, HIF-1 alpha is hydroxylated and degraded, whereas under hypoxic conditions, it is stabilized and transcriptionally active.
HIF-1 beta remains stable under both conditions and plays a role in diseases such as hypoxia and renal cell carcinoma.
Hypoxia contributes to various pathological conditions including myocardial and cerebral ischemia, cancer, pulmonary hypertension, congenital heart disease, and chronic obstructive pulmonary disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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