Thermo Fisher Scientific SKIL Monoclonal Antibody (OTI3E2), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis.
This signaling is negatively regulated by Ski and the related protein SnoN, which function by binding to Smad proteins and preventing their phosphorylation, thereby inhibiting their ability to bind DNA and activate transcription of downstream genes.
SnoN is primarily located in the nucleus in cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.