Thermo Fisher Scientific SKIL Monoclonal Antibody (OTI1A6), TrueMAB
SKIL 단백질을 인식하는 Mouse IgG1 단일클론 항체로 Western blot과 IHC(Paraffin)에 적합. 인간 시료 반응성, 무보존제 PBS 버퍼에 동결건조 형태로 제공. 연구용으로 TGF-beta/Smad 신호 조절 관련 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 307–684 of human SKIL produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
TGF-beta is a ubiquitously expressed cytokine that signals through the Smad protein family to regulate numerous cellular processes such as embryonic development and tumorigenesis.
This signaling is negatively regulated by Ski and SnoN proteins, which bind Smad proteins and prevent their phosphorylation, thereby inhibiting DNA binding and downstream gene transcription.
SnoN is primarily located in the nucleus of cancer tissues or cells, but in the cytoplasm in normal tissues or primary epithelial cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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