Thermo Fisher Scientific Phospho-Caveolin 1 (Tyr14) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

This antibody detects endogenous levels of Caveolin-1 only when phosphorylated at Tyrosine 14.

Target Information

Caveolin-1 (CAV1) is a scaffolding protein within caveolar membranes that interacts directly with G-protein alpha subunits and regulates their activity. It plays a role in co-stimulatory signaling essential for T-cell receptor (TCR)-mediated T-cell activation. Caveolin-1 can bind with DPP4 and induce T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Mutations in the CAV1 gene are associated with congenital generalized lipodystrophy 3, pulmonary hypertension primary 3, and partial lipodystrophy/congenital cataracts with neurodegeneration syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.