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Thermo Fisher Scientific Phospho-LRP6 (Ser1490) Polyclonal Antibody
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LRP6 단백질의 Ser1490 인산화 부위를 특이적으로 인식하는 폴리클로날 항체로, 인간, 생쥐, 랫트 시료에 반응합니다. Western blot에 적합하며, 고순도 액상 형태로 제공됩니다. Wnt/β-catenin 신호 연구에 유용합니다.
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마지막 업데이트 2025. 07. 31. 오후 05:16
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Thermo Fisher Scientific PA5101046 Phospho-LRP6 (Ser1490) Polyclonal Antibody 100 ul pk판매 단위 pk ·
재고 확인 필요
627,600원VAT 포함 690,360원
Thermo Fisher Scientific · Thermo Fisher Scientific Phospho-LRP6 (Ser1490) Polyclonal Antibody
Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human LRP6 (Accession O75581), corresponding to amino acid residues around phosphorylated Ser1490 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815875 |
Product Specific Information
This antibody detects endogenous levels of LRP6 only when phosphorylated at Ser1490.
Target Information
LRP6 is essential for the Wnt/β-catenin signaling pathway, acting as a coreceptor with Frizzled for Wnt. It serves as a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. Interaction with DKK1 inhibits LRP6-mediated signaling through Kremen protein-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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