Thermo Fisher Scientific Phospho-IP3 Receptor 1 (Ser1756) Polyclonal Antibody
IP3 Receptor 1의 Ser1756 인산화 부위를 인식하는 rabbit polyclonal antibody. Western blot과 immunocytochemistry에 적합. Human, Mouse, Rat 시료에 반응. 고순도 액상 형태로 -20°C 보관.
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- PA5101050
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from rat ITPR1 (Accession Q14643), corresponding to amino acid residues around phosphorylated Ser1756 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2815879 |
Product Specific Information
Antibody detects endogenous levels of IP3 Receptor only when phosphorylated at Ser1756.
Target Information
Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by activation of CaM kinase II, leading to downstream apoptosis pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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