Thermo Fisher Scientific Phospho-CHK1 (Ser317) Polyclonal Antibody
Phospho-CHK1 (Ser317) 폴리클로날 항체로 인간, 생쥐, 랫트 시료에 반응하며 Western blot, IHC, ELISA에 적합. 항원 친화 크로마토그래피로 정제된 액상 항체로, DNA 손상 반응 연구에 활용 가능. Thermo Fisher Scientific 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:5,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Chk1 around the phosphorylation site of S317 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610436 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 acts as a key mediator in the DNA damage-induced checkpoint network and ensures genomic integrity under genotoxic stress. Inhibition of CHK1 can lead to mitotic catastrophe and apoptosis in p53-deficient cancer cells, making CHK1 an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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