Thermo Fisher Scientific Phospho-GRF-1 (Tyr1087) Polyclonal Antibody
Phospho-GRF-1 (Tyr1087) 폴리클로날 항체로 인간, 마우스, 랫트에 반응합니다. Western blot과 ELISA에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 완충액에 보관되며, 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA540199
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| ELISA | 1:10,000 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human GRF-1 around the phosphorylation site of Y1087 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2577035 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
RNA polymerase (Pol) III synthesizes tRNA, 5S rRNA, 7SL RNA, and U6 snRNA and is overexpressed in many transformed cell lines and tumors in vivo. To maintain rapid growth, cells must produce a high level of Pol III transcribed RNA, requiring TFIIIB and TFIIIC2 transcription factor complexes.
The TFIIIC2 complex (composed of TFIIIC220, TFIIIC110, TFIIIC102, TFIIIC90, and TFIIIC63) is overexpressed in malignant cells such as ovarian carcinomas and recruits RNA Pol III and TFIIIB to promoter elements. The TFIIIB complex includes TBP, TFIIIB90 (BRF1), and other factors whose expression is upregulated in transformed cells.
In many carcinomas, tumor suppressors RB and p53 are inactivated, impairing their ability to regulate TFIIIB function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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