Thermo Fisher Scientific Phospho-STAT6 (Thr645) Polyclonal Antibody
Phospho-STAT6 (Thr645) 특이적 폴리클로날 항체로 인간, 마우스, 랫트에 반응. IHC 및 IP에 사용 가능하며, 고순도(>95%) 항원 친화 크로마토그래피 정제. 94 kDa 단백질 검출에 적합하며 연구용으로만 사용.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human Stat6 around the phosphorylation site of Threonine 645 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2553663 |
Product Specific Information
- Detects endogenous protein at a molecular weight of 94 kDa.
- Purity is >95% by SDS-PAGE.
Target Information
STAT6 protein is a transcription factor activated by cytokines, particularly interleukin-4 and IL13. STAT6-deficient mice (Stat6-/-) show impaired IL-4-mediated functions including Th2 helper T-cell differentiation, expression of cell surface markers, T-cell proliferation, immunoglobulin class switching to IgE, and partial loss of IL-4 mediated proliferation.
STAT6 mRNA is expressed in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta.
STAT6 is critically involved in Th2 immune response and IL-4-mediated biological processes, existing in two isoforms: STAT6a and STAT6c.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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