Thermo Fisher Scientific TRAF1 (TNFR-Associated Factor 1) Monoclonal Antibody (TRAF1, 2770)
인간 TRAF1 단백질을 인식하는 Mouse monoclonal 항체로, IHC(P) 및 Peptide Array에 사용 가능. 단백질 A/G 정제, PBS buffer에 보존. TNFR 신호전달 연구 및 항-아포토시스 경로 분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TRAF1, 2770 |
| Immunogen | Recombinant fragment of human TRAF1 protein (around aa 73–219) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage conditions | -20°C or -80°C if preferred |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
The protein encoded by the TRAF1 gene is a member of the TNF receptor (TNFR)-associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from various receptors of the TNFR superfamily.
TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors.
Expression of TRAF1 can be induced by Epstein-Barr virus (EBV). EBV latent membrane protein 1 (LMP1) interacts with TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signal transduction.
Three transcript variants encoding two different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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