Thermo Fisher Scientific TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Monoclonal Antibody (TRAF1/3298)
인간 TRAF1 단백질을 인식하는 단클론 항체로, IHC(P), IHC(PFA), Peptide Array 등 다양한 응용에 사용 가능. TNFR 신호전달 연구 및 림프종 관련 표지자 분석에 적합. 4°C 보관, Protein A/G 정제, PBS 기반 저장용액 포함.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TRAF1/3298 |
| Immunogen | Recombinant fragment of human TRAF1 protein (around aa 73–219) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the TNF receptor (TNFR)-associated factor (TRAF) family. TRAF proteins mediate signal transduction from TNFR superfamily receptors.
TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB.
This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors.
Expression of this protein can be induced by Epstein-Barr virus (EBV). EBV membrane protein 1 (LMP1) interacts with TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signaling.
Three transcript variants encoding two isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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