Thermo Fisher Scientific TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) Monoclonal Antibody (TRAF1/3298)
인간 TRAF1 단백질을 인식하는 단클론 항체로, IHC 및 Peptide Array 등 다양한 응용 가능. TRAF1/3298 클론을 사용하며, PBS 기반 무보존액 형태로 제공. TNFR 신호전달 및 항아포토시스 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TRAF1/3298 |
| Immunogen | Recombinant fragment of human TRAF1 protein (around aa 73–219) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from various receptors of the TNFR superfamily. TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), contributing to anti-apoptotic signaling. Expression of TRAF1 can be induced by Epstein-Barr virus (EBV), and its interaction with EBV LMP1 protein links viral transformation to TNFR-mediated signaling. Three transcript variants encoding two different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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