Thermo Fisher Scientific TRAF1 (TNFR-Associated Factor 1) Monoclonal Antibody (TRAF1, 2770)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1–2 µg/mL

Peptide Array (Array)

• Tested Dilution: Assay-dependent

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): incubate antibody for 30 min at room temperature (RT).
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at RT for 20 minutes.

Target Information

The TRAF1 gene encodes a member of the TNF receptor-associated factor (TRAF) protein family. TRAF proteins mediate signal transduction from receptors of the TNFR superfamily.
TRAF1 and TRAF2 form a heterodimeric complex required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB.
This complex also interacts with inhibitor-of-apoptosis proteins (IAPs), mediating anti-apoptotic signals from TNF receptors.
Expression of TRAF1 can be induced by Epstein-Barr virus (EBV), and EBV membrane protein 1 (LMP1) interacts with TRAF1 and other TRAF proteins, linking LMP1-mediated B lymphocyte transformation to TNFR signaling.
Three transcript variants encoding two different isoforms have been identified for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.