Thermo Fisher Scientific FERMT3 Monoclonal Antibody (OTI3C7), TrueMAB
Human FERMT3 단백질(Kindlin 3)을 인식하는 마우스 단클론 항체로, Western blot 및 파라핀 조직 면역조직화학(IHC-P)에 적합합니다. 동결건조 형태로 제공되며, PBS와 트레할로스 완충액에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3C7 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 259–528 of human FERMT3 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
The three KINDLINs constitute a novel family of focal adhesion proteins localized to integrin adhesion sites. They contain a central FERM domain interrupted by a pleckstrin homology (PH) domain.
KINDLIN1 and KINDLIN2 are widely expressed and play key roles in integrin-mediated adhesion and spreading, while KINDLIN3 is restricted to hematopoietic cells, particularly megakaryocytes and platelets.
KINDLIN3 is essential for platelet integrin activation and outside-in signaling, making it a potential target for therapeutic strategies aimed at modulating integrin activation in platelets and leukocytes.
Transcriptional dysregulation of KINDLINs has been reported in various cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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