Thermo Fisher Scientific beta-2 Microglobulin Polyclonal Antibody
Rat 유래 beta-2 Microglobulin을 인식하는 Goat Polyclonal Antibody. Western blot 및 Flow cytometry에 적합. 항원 친화 크로마토그래피로 정제된 동결건조 제형. PBS(5% 트레할로스) 완충액, 방부제 무첨가. -20°C 보관, 동결/해동 반복 피할 것.
- 카탈로그번호
- PA546943
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Flow Cytometry (Flow) | 2.5 µg per million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mouse myeloma cell line NS0-derived recombinant rat beta 2-Microglobulin (Ile21–Met119) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2609664 |
Product Specific Information
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the MHC class I complex. It is expressed on various cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes. It also circulates freely in plasma.
The amino acid sequence of beta-2-microglobulin is homologous to immunoglobulin constant regions, forming a β-pleated sheet structure. It is involved in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells. The B2M gene is located on chromosome 15, and mutations can cause hypercatabolic hypoproteinemia. Beta-2-microglobulin levels are used as a renal function marker and prognostic indicator for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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