Thermo Fisher Scientific PIP5K1C Polyclonal Antibody
PIP5K1C 단백질 검출용 Rabbit Polyclonal 항체. Western blot에 최적화되어 있으며 Human, Mouse, Rat 시료에 반응. 항원 친화 크로마토그래피로 정제된 고순도 항체. 연구용으로 세포 이동 및 신호전달 연구에 적합.
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Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 346–391 of Human PIP5K1C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C (short term). For long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719277 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase 1 gamma) is a lipid kinase that phosphorylates phosphatidylinositol-4-phosphate to form phosphatidylinositol 4,5-bisphosphate. It is localized at synapses and plays roles in endocytosis and cell migration. PIP5K1C interacts with β-catenin, enhancing its activity downstream of growth factor stimulation. Its expression and kinase activity promote β-catenin phosphorylation, nuclear import, and transcriptional activity. Deficiency in PIP5K1C impairs neutrophil recruitment due to defective adhesion, mediated by RhoA GTPase and integrin activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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