Thermo Fisher Scientific TSPO Polyclonal Antibody
TSPO 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 고순도(>95%) 항체로 연구용으로 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 5 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:200 | View publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 124–169 of Human TSPO |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719272 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
Mitochondrial peripheral-type benzodiazepine receptor (PBR), also known as TSPO, plays a critical role in steroidogenesis by mediating cholesterol transport into mitochondria. It consists of multiple subunits including an isoquinoline binding site, voltage-dependent anion channel, and adenine nucleotide carrier. PBR is evolutionarily conserved and expressed in various peripheral tissues, with limited expression in the brain, mainly in glial cells. PFDA (perfluorodecanoic acid) inhibits Leydig cell steroidogenesis by decreasing PBR mRNA stability and expression, thereby reducing cholesterol transport and steroid formation. PRAX-1 (Peripheral Benzodiazepine Receptor-Associated Protein 1) specifically interacts with PBR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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