Thermo Fisher Scientific Phospho-STAT5 alpha/beta (Ser726, Ser731) Polyclonal Antibody
STAT5 α/β 인산화(Ser726, Ser731) 검출용 폴리클로날 항체로, 인간·마우스·랫트 반응성. Western blot, IHC, ELISA에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품. 세포 신호전달 및 종양 형질 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (IHC) | 1:100–1:300 |
| ELISA | 1:40,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human Stat5 around the phosphorylation site of S726/731 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 0.5% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2608796 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators.
This protein is activated by, and mediates responses of, various ligands such as IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin, and growth hormones.
Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and is essential for tumorigenesis.
The mouse counterpart induces expression of BCL2L1/BCL-X(L), suggesting an antiapoptotic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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