Thermo Fisher Scientific THRB Monoclonal Antibody (2386)
인간 THRB 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot에 적합합니다. 단백질 G로 정제된 액상 형태이며, 보존제가 포함되지 않습니다. -20°C에서 보관하며, 연구용으로만 사용됩니다.
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Thermo Fisher Scientific THRB Monoclonal Antibody (Clone 2386)
Applications
- Western Blot (WB): Tested dilution 1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2386 |
| Immunogen | Synthetic peptide corresponding to the N-terminal region of human THRB conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein G |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_561702 |
Product Specific Information
This antibody is specific for the ~55 kDa THR-beta protein.
Target Information
Thyroid hormone receptors (TR), also known as c-erbA-2, are ligand-dependent intracellular proteins that stimulate transcription of specific genes by binding to hormone response elements following activation by the appropriate hormone.
Thyroid hormones regulate metabolic processes, growth, and development in many tissues through TR-mediated gene expression.
There are two forms of TR: TR alpha (chromosome 17) and TR beta (chromosome 3), each with two isoforms (TR alpha-1/alpha-2 and TR beta-1/beta-2).
TR alpha-1 and TRv alpha-2 are identical through amino acid 370, where their sequences diverge. TRv alpha-2 does not bind T3 and acts as a strong negative regulator of functional TR.
The corresponding gene for thyroid hormone receptor beta-1 is NR1A2.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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