Thermo Fisher Scientific pro BDNF Polyclonal Antibody
Rabbit polyclonal antibody recognizing proBDNF in human, mouse, and rat samples. Validated for WB and IHC applications. Lyophilized form, reconstitutable in sterile water. Suitable for neuroscience and neurotrophin signaling research.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 10–50 µg/mL | - |
| Immunohistochemistry (IHC) | 10–50 µg/mL | - |
| Miscellaneous (PubMed) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse pro BDNF conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: proBDNF.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a neurotrophin family member synthesized as pre-proBDNF, cleaved to proBDNF, and further processed to the mature 14 kDa protein. Both proBDNF and mature BDNF are biologically active and secreted in synaptic vesicles.
BDNF is widely expressed in the CNS, promoting neuronal survival and differentiation, and plays key roles in memory formation and synaptic regulation. It signals primarily through the TrkB receptor and also interacts with the p75-NTR receptor. Reduced BDNF expression is associated with Alzheimer’s and Huntington’s diseases, and it may influence stress response and mood regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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