Thermo Fisher Scientific BDNF Polyclonal Antibody
Rabbit polyclonal antibody targeting mature BDNF. Validated for WB and IHC (Paraffin) with 1:1,000 dilution. Recognizes human, mouse, and rat BDNF. Lyophilized form, reconstitute in sterile water. Suitable for research on neuronal survival and differen...
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the N-terminal region of human mature BDNF conjugated to a blue carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in many other species including rat, mouse, zebrafish, and xenopus.
- Specificity: mature BDNF.
Target Information
BDNF (Brain-Derived Neurotrophic Factor) is a member of the neurotrophin family. It is synthesized as pre-proBDNF, then cleaved to proBDNF, and further processed to the mature 14 kDa protein. Both pro-BDNF and mature BDNF are biologically active and secreted in synaptic vesicles.
BDNF is widely expressed in the central nervous system and acts on several classes of neurons through the TrkB receptor and the lower-affinity receptor p75-NTR. It promotes neuronal survival and differentiation and plays a critical role in memory formation and synaptic regulation.
Reduced BDNF expression has been observed in Alzheimer’s and Huntington’s disease and may also be involved in stress response and mood disorder regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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