Thermo Fisher Scientific FGFR1 Monoclonal Antibody (1B12)
인간 FGFR1 단백질을 표적으로 하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone 1B12). Western blot 및 ELISA에 적합하며, PBS 기반 액상 형태로 제공. -20°C 보관, 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-Dependent
ELISA
- 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B12 |
| Immunogen | FGFR1 (NP_000595.1, 303–408 a.a) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
DNLPYVQILK TAGVNTTDKE MEVLHLRNVS FEDAGEYTCL AGNSIGLSHH SAWLTVLEAL EERPAVMTSP LYLEIIIYCT GAFLISCMVG SVIVYKMKSG TKKSDF
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which serve as high-affinity receptors for 17 growth factors (FGF1–17).
The FGF receptor family is involved in critical biological processes such as mesoderm induction, cell growth, migration, organ formation, and bone development.
FGFR1 undergoes alternative splicing, generating multiple variants expressed during embryonic development and in adults.
Defects in FGFR1 are linked to various diseases, including:
- Pfeiffer syndrome (PS)
- Idiopathic hypogonadotropic hypogonadism (IHH)
- Kallmann syndrome type 2 (KAL2)
- Osteoglophonic dysplasia (OGD)
- Non-syndromic trigonocephaly
- Jackson-Weiss syndrome
- Antley-Bixler syndrome
Chromosomal aberrations involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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