Thermo Fisher Scientific PGP9.5 Polyclonal Antibody
PGP9.5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, 인간·마우스·랫트 반응성 확인. WB 및 IHC(P/F) 응용 가능. 신경세포 및 신경계 연구용으로 적합하며, 신경퇴행성 질환 연구에 활용 가능.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:10,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human PGP9.5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.56 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.1M tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2792271 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (95%), Rat (95%), Pig (96%), Bovine (95%).
- Positive Control: A549, H1299, Mouse brain, Rat brain.
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
PGP9.5 (Protein gene product 9.5, UCH-L1, PARK5) is a neuron-specific protein, structurally and immunologically distinct from neuron-specific enolase. It has a molecular weight of 27 kDa and belongs to the ubiquitin carboxyl-terminal hydrolase family 1 (peptidase family C12). PGP9.5 exhibits ubiquitin hydrolase and ligase activities, hydrolyzing small C-terminal adducts of ubiquitin to generate ubiquitin monomers.
PGP9.5 is present in neurons and nerve fibers throughout the central and peripheral nervous system, neuroendocrine cells, renal tubules, spermatogonia, Leydig cells, ova, and corpus luteum cells. Overexpression is associated with non-small cell lung cancer, while decreased expression relates to Huntington and Alzheimer diseases. It serves as a useful neuronal marker and is valuable for studying neurodegenerative disorders such as Parkinson’s disease.
⚠ WARNING: This product can expose you to chemicals including mercury, known to the State of California to cause birth defects or other reproductive harm. For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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