Thermo Fisher Scientific APAF1 Polyclonal Antibody
APAF1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체로, IHC(P)에서 1:100~1:1,000 희석으로 사용 가능. Human, Mouse, Rat에 반응하며 항원 친화 크로마토그래피로 정제됨. 세포 사멸 연구용으로 적합.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human APAF1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.51 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C (short term). For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792268 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (85%), Rat (85%), Bovine (90%).
- Positive Control: Target recombinant protein.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
APAF1 (Apoptotic Protease Activating Factor 1)
APAF1 유전자는 세포질 단백질을 암호화하며, 세포사멸(apoptosis)을 개시하는 역할을 합니다. 이 단백질은 WD-40 도메인, caspase recruitment domain (CARD), ATPase domain (NB-ARC)을 포함합니다. Cytochrome c와 dATP 결합 시, oligomeric apoptosome을 형성하며 caspase 9를 활성화시켜 세포사멸 연쇄반응을 유도합니다. 대체 스플라이싱으로 다양한 isoform이 생성될 수 있습니다.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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