Thermo Fisher Scientific PSMD2 Monoclonal Antibody (OTI1G8), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The 26S proteasome is a multicatalytic proteinase complex composed of two subcomplexes: a 20S core and a 19S regulator.

• The 20S core consists of four rings of 28 subunits (two alpha and two beta rings).
• The 19S regulator includes a base (with ATPase and non-ATPase subunits) and a lid (with up to 10 non-ATPase subunits).

Proteasomes are abundant in eukaryotic cells and degrade peptides through an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome variant processes class I MHC peptides.
PSMD2 encodes a non-ATPase subunit of the 19S regulator lid and may also play a role in TNF signaling via interaction with the TNF type 1 receptor.
A pseudogene is located on chromosome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.