Thermo Fisher Scientific Phospho-HSP27 (Ser78) Recombinant Rabbit Monoclonal Antibody (JJ08-70)
인간 HSP27 Ser78 인산화 부위를 특이적으로 인식하는 재조합 토끼 단클론 항체입니다. Western blot, IHC, ICC/IF에 적합하며 높은 특이성과 재현성을 제공합니다. Protein A로 정제된 액상 형태로, 연구용으로 사용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ08-70 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Ser78 of human Hsp27 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2898926 |
Target Information
In response to adverse environmental changes, cells from many organisms increase the expression of heat shock or stress proteins.
HSPB1 (heat shock protein beta-1 or HSP27) is a small heat shock protein functioning as a molecular chaperone that maintains denatured proteins in a folding-competent state.
It plays a role in stress resistance and actin organization. Through its chaperone activity, HSP27 regulates biological processes including phosphorylation and axonal transport of neurofilament proteins.
Mutations in the gene can result in Charcot-Marie-Tooth disease 2F and distal hereditary motor neuronopathy 2B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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