Thermo Fisher Scientific cGMP Monoclonal Antibody (2F11E10), THE

Applications

Tested Dilution

Publications

ELISA (ELISA)

0.04-0.1 µg/mL

-

Miscellaneous PubMed (Misc)

-

View 1 publication 1 publication

Product Specifications

Published species

Not Applicable

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

2F11E10

Immunogen

3, 5-cyclic GMP-8-KLH

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.

Guanosine 3, 5-cyclic monophosphate (cyclic GMP; cGMP) acts as a secondary messenger much like cyclic AMP. It is generally known to activate intracellular protein kinases in response to the binding of membrane-impermeable peptide hormones to the cell surface. cGMP synthesis is catalyzed by guanylate cyclase (GC), which converts GTP to cGMP. Membrane-bound GC is activated by peptide hormones such as atrial natriuretic factor, while soluble GC is typically activated by nitric oxide (NO) to stimulate cGMP synthesis.cGMP is also a common regulator of ion channel conductance, glycogenolysis, and cellular apoptosis. It also relaxes smooth muscle tissues. The roles of cGMP and cAMP may be linked, as evidenced by the fact that some cellular functions are controlled bi-directionally by both cAMP and cGMP. Some functions are stimulated by cGMP and suppressed by cAMP and vice versa.GenScript THE™ cGMP Antibody, mAb, Mouse is developed using 3, 5-cyclic GMP-8-KLH as immunogen.

Target Information

Guanosine cyclic 3,5-(hydrogen phosphate) is a guanine nucleotide containing one phosphate group which is esterified to the sugar moiety in both the 3- and 5-positions. Cyclic gmp is a cellular regulatory agent and has been described as a second messenger. Its levels increase in response to a variety of hormones, including acetylcholine, insulin, and oxytocin and it has been found to activate specific protein kinases. [National Center for Biotechnology Information. PubChem Compound Database; CID=24316].

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.