Thermo Fisher Scientific CD89 Monoclonal Antibody (MIP8a)

Applications and Tested Dilution

Product Specifications

Additional Formats

• PE Conjugate (MA5-28107)
• Request custom conjugation

Product Specific Information

This antibody recognizes the human CD89 cell surface antigen, a 50–75 kDa glycoprotein also known as the IgA receptor (Fc alpha R). CD89 is expressed by peripheral blood monocytes and neutrophils. The MIP8a clone blocks IgA binding to Fc alpha R and inhibits neutrophil phagocytosis of IgA complexes.

Target Information

The CD89 gene encodes a receptor for the Fc region of IgA and belongs to the immunoglobulin gene superfamily. It is a transmembrane glycoprotein expressed on myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils. This receptor mediates immune responses to pathogens by interacting with IgA-opsonized targets, triggering phagocytosis, antibody-dependent cell-mediated cytotoxicity, and release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.