Thermo Fisher Scientific Phospho-ATF2 (Thr71) Polyclonal Antibody
ATF2 단백질의 Thr71 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제된 고순도 항체로, 다양한 종에서 보존된 서열 기반. 연구용으로만 사용.
- 카탈로그번호
- 44295G
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-ATF2 (Thr71) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Chemically synthesized phosphopeptide derived from a region of human ATF2 that contains threonine 71 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | Dulbecco's PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533624 |
Product Specific Information
This antibody has been negatively preadsorbed using a non-phosphopeptide corresponding to the site of phosphorylation to remove antibody that is reactive with non-phosphorylated ATF2.
The final product is generated by affinity chromatography using an ATF2-derived peptide phosphorylated at threonine 71.
The peptide sequence is conserved in mouse, rat, chicken, and frog.
Suggested Western blot positive controls: NIH3T3 + anisomycin, or Jurkat + 10 µg/mL anisomycin for 60 minutes.
Target Information
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins.
ATF-2 interacts with various viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways.
Cellular stress, including genotoxic agents, inflammatory cytokines, and UV irradiation, stimulates the transcriptional activity of ATF-2.
Activation occurs through phosphorylation of Thr69 and Thr71, mediated by SAPK and p38 MAPK.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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