Thermo Fisher Scientific TAB3 Polyclonal Antibody
Rabbit 유래의 Polyclonal TAB3 항체로, Human 시료에 반응합니다. IHC에 5 µg/mL 농도로 사용 가능하며, NF-κB 신호전달 및 자가포식 연구에 유용합니다. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 제공됩니다.
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 13 amino acid synthetic peptide near the amino terminus of human TAB3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551718 |
Product Specific Information
- A suggested positive control is human kidney tissue.
- PA5-34366 can be used with blocking peptide PEP-1409.
Target Information
TAB3 functions in the NF-κB signal transduction pathway. Together with TAB2, it forms a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to TNF or IL-1 stimulation. TAK1 activation leads to NF-κB transcription factor activation.
Recent studies show that TAB2 and TAB3 interact with the autophagy mediator Beclin-1; upon autophagy induction, they dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibits autophagy, while depletion triggers it, suggesting their role as a control point for autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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