Thermo Fisher Scientific RIM2 Polyclonal Antibody
RIM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 인간 시료에 반응하며, IHC에 적합. 항원 친화 크로마토그래피로 정제된 고순도 제품. 단기 냉장 및 장기 냉동 보관 가능.
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Thermo Fisher Scientific RIM2 Polyclonal Antibody
Applications
- Immunohistochemistry (IHC)
Tested Dilution: 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 17 amino acid synthetic peptide near the center of human RIM2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551719 |
Product Specific Information
- Suggested positive control: human brain tissue
- PA5-34367 can be used with blocking peptide PEP-1410
Target Information
Rab3-interacting molecules (RIMs) are synaptic proteins essential for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. Deletion of both genes in mice results in postnatal mortality due to defects in neurotransmitter release. Synapses lacking RIM proteins can release neurotransmitters but fail to respond to normal Ca²⁺ triggers. Like Rim1, Rim2 functions as an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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