Thermo Fisher Scientific TTBK2 Polyclonal Antibody
TTBK2 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC에 적합합니다. Human 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 2–8°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
- Immunohistochemistry (IHC): 5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid synthetic peptide near the carboxy terminus of human TTBK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at -20°C. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551721 |
Product Specific Information
PA5-34369 can be used with blocking peptide PEP-1412.
Target Information
Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include tau and tubulin proteins.
Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and cerebellar atrophy.
Increased TTBK2 expression in kidney carcinoma and melanoma cell lines has been associated with resistance to the chemotherapeutic agent Sunitinib. Reduction of TTBK2 expression via siRNA sensitizes these cell lines to Sunitinib, suggesting TTBK2 as a potential resistance marker and therapeutic target.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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