Thermo Fisher Scientific Cathepsin A Polyclonal Antibody

Applications

• Western Blot (WB): 1:500–1:1,000 dilution

Product Specifications

Product Specific Information

• Purity is >95% by SDS-PAGE.

Target Information

The cathepsin family of proteolytic enzymes includes several diverse classes of proteases.
Cathepsins B, L, H, K, S, and O comprise the cysteine protease class.
Cathepsins D and E comprise the aspartyle protease class.
The serine protease class includes cathepsin G.

Cathepsins function in cellular metabolism and participate in peptide biosynthesis and protein degradation.
Cathepsin A, a serine carboxypeptidase, exists in a high molecular weight lysosomal complex with β-galactosidase (β-gal) and α-neuraminidase (Neu1).
Cathepsin A protects β-gal and Neu1 from intralysosomal proteolysis.
Deficiencies in cathepsin A lead to deficiencies in β-gal and Neu1.
The gene encoding human cathepsin A maps to chromosome 20q13.12.
Mutations in this gene cause galactosialidosis, a lysosomal storage disorder resulting from β-gal and Neu1 deficiencies.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.