Thermo Fisher Scientific ABCA1 Polyclonal Antibody
ABCA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 종에서 반응하며 WB, IHC, ICC, Flow 등 여러 응용에 사용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태, 4°C 단기 및 -20°C 장기 보관 권장.
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Thermo Fisher Scientific ABCA1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | View 10 publications |
| Immunohistochemistry (IHC) | – | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 | – |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | – |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
| Flow Cytometry (Flow) | 1:400 | – |
| ELISA | Assay-Dependent | – |
| Immunoprecipitation (IP) | 1:10–1:500 | – |
| ChIP assay (ChIP) | Assay-Dependent | – |
| Neutralization (Neu) | Assay-Dependent | – |
| Gel Shift (GS) | Assay-Dependent | – |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Chicken, Hamster, Human, Mustelid, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Published Species | Human, Mouse |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Partial peptide sequence corresponding to residues 1100–1300 of human ABCA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2288917 |
Product Specific Information
ABCA1 is known to aggregate.
DO NOT BOIL SAMPLES.
Target Information
Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD), an autosomal recessive disorder characterized by the absence of plasma HDL, cholesterol ester deposition in the reticulo-endothelial system, and deviations in cellular lipid trafficking.
ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and Golgi complex, and is regulated by cholesterol flux.
Regulation of cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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