Thermo Fisher Scientific HEXB Polyclonal Antibody
Human HEXB 단백질을 인식하는 Rabbit Polyclonal 항체로, IHC(P)에서 1:500~1:1000 희석 비율로 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol buffer에 보관. Sandhoff 질환 연구 등 HEXB 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HEXB. Recombinant protein control fragment (Product # RP-100908) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642406 |
Product Specific Information
Immunogen sequence:
PSVSAKPGPA LWPLPLSVKM TPNLLHLAPE NFYISHSPNS TAGPSCTLLE EAFRRYHGYI
Sequence identity to orthologs:
- Mouse: 60%
- Rat: 60%
Target Information
Hexosaminidase B (HEXB), also designated beta-hexosaminidase B, is a tetramer composed of two β-A and two β-B chains, localized in the lysosomes. Mutations in the HEXB gene cause Sandhoff disease (GM2-gangliosidosis type II), an autosomal recessive disorder leading to accumulation of GM2 ganglioside and progressive destruction of the central nervous system. Sandhoff disease is similar to Tay-Sachs disease (HEXA gene mutation) but generally more severe.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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