Thermo Fisher Scientific UCP1 Polyclonal Antibody
UCP1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin)에서 사용 가능. Human과 Mouse에 반응하며, 항원 친화 크로마토그래피로 정제됨. 단기 4°C, 장기 -20°C 보관 권장.
- 카탈로그번호
- PA585690
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human UCP1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.37 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792829 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%).
- Positive Control: Mouse brown adipose tissue.
- Store product as a concentrated solution.
- Centrifuge briefly prior to opening the vial.
Target Information
Mitochondrial uncoupling proteins (UCPs) are members of the mitochondrial anion carrier protein family. They separate oxidative phosphorylation from ATP synthesis, dissipating energy as heat (mitochondrial proton leak). UCPs facilitate anion transfer across the mitochondrial membrane and proton return transfer, reducing mitochondrial membrane potential.
UCP1 is expressed specifically in brown adipose tissue, which functions in heat production. The exact mechanism of proton transfer by UCPs remains unclear, though they contain three homologous MACP domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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