Thermo Fisher Scientific CD61 (Integrin beta 3) Monoclonal Antibody (M581)
CD61 (Integrin beta 3) 단일클론 항체로 인간, 마우스, 랫트 시료에 반응. Western blot 및 면역형광에 적합. 단백질 A로 정제된 액상 항체로, -20°C에서 보관. 혈소판 및 내피세포의 Integrin beta3 검출에 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M581 |
| Immunogen | Clone M581 was generated from a recombinant protein containing amino acid residues in the extracellular region of human Integrin beta3. This sequence has high homology with rat and mouse Integrin beta3, and has low homology to other integrin family members. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.08 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942702 |
Product Specific Information
This antibody detects a 100 kDa protein corresponding to the molecular mass of Integrin beta3 on SDS-PAGE immunoblots of human platelets and endothelial cells (HUVEC).
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It plays a key role in platelet aggregation and serves as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
CD61 is a 105 kDa glycoprotein that associates with either alpha IIb integrin (CD41) or alpha V integrin (CD51) at the cell surface. It is expressed on platelets and megakaryocytes (with CD41) and on endothelial cells, monocytes, and osteoclasts (with CD51).
CD61 participates in cell adhesion and cell-surface mediated signaling. Dysfunctions are associated with Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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