Thermo Fisher Scientific SHISA3 Polyclonal Antibody
SHISA3 단백질을 검출하기 위한 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC에 사용 가능. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용 가능.
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Thermo Fisher Scientific SHISA3 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide near the center of human SHISA3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551879 |
Product Specific Information
A suggested positive control is human small intestine tissue lysate.
PA5-34527 can be used with blocking peptide PEP-1570.
Target Information
SHISA3 plays an essential role in the maturation of presomitic mesoderm cells by attenuation of both FGF and WNT signaling.
The Shisa family of single-transmembrane proteins is characterized by an N-terminal cysteine-rich domain and a proline-rich C-terminal region.
Its founding member, Xenopus Shisa, promotes head development by antagonizing Wnt and FGF signaling.
Shisa physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the ER, inhibiting their posttranslational maturation and trafficking to the cell surface.
Loss of Shisa function sensitizes the neuroectoderm to Wnt signaling and suppresses head formation during gastrulation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures.
Not for resale without express authorization.
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배송 정보
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