Thermo Fisher Scientific IFRD1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human IFRD1. Recombinant protein control fragment (Product #RP-92274). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IFRD1,uniProtId:O00458-1,ncbiNodeId:9606,antigenRange:328-413,antigenLength:451,antigenImageFileName:PA5-54985_IFRD1_O00458-1_Rabbit.svg,antigenImageFileNamePDP:PA5-54985_IFRD1_O00458-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642645

Product Specific Information

Immunogen sequence: AKVDKRKQRS VFRDVLRAVE ERDFPTETIK FGPERMYIDC WVKKHTYDTF KEVLGSGMQY HLQSNEFLRN VFELGPPVML DAATLK

Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 95%.

Target Information

Tis7, also known as IFRD1, is a 442 amino acid containing membrane associated, non-nuclear intracellular protein belonging to the IFRD family. A regulatory protein expressed in a variety of tissues, Tis7 is known to play an important role in the regulation of gene activity in the proliferative and/or differentiative pathways induced by NGF. Reports suggest that Tis7 may be an autocrine factor that attenuates or amplifies the initial ligand induced signal and might also augment the adaptive response by stimulating the production of differentiated enterocytes. Tis7 acts as a negative regulator of transcriptional activity and represses expression of genes involved in myogenesis, muscle maintenance, and regeneration in a histone deacetylase dependent manner.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.