Thermo Fisher Scientific MET Monoclonal Antibody (OTI2B5), TrueMAB
Human MET 단백질(aa 125-421)을 인식하는 Mouse IgG2b 단일클론 항체로, Western blot에 최적화됨. TrueMAB 형식의 고순도 항체로 1 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 암 및 발달 관련 MET 신호 연구용에 적합.
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- TA804884
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 125–421 of human MET produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
MET (c-MET) is a receptor-like tyrosine kinase whose dysregulation has been linked to many types of human malignancies. After activation by its ligand, MET interacts with PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, and STAT3, leading to activation of signaling cascades including RAS-ERK, PI3K-AKT, and PLCγ-PKC pathways.
MET is involved in embryonic development processes such as gastrulation, muscle and neuron formation, angiogenesis, and kidney development. In adults, it plays roles in wound healing, organ regeneration, and tissue remodeling.
MET has been associated with several cancers including gastric, renal, and breast, making it an important target for cancer therapeutics and diagnostic testing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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