Thermo Fisher Scientific RelB Polyclonal Antibody
RelB 단백질을 인식하는 토끼 다클론 항체로, Western blot 및 Immunoprecipitation에 적합합니다. 인간, 마우스, 랫트, 영장류 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 보존제 없이 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunoprecipitation (IP) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues surrounding Ser424 of human RelB protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977839 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other family members at physiological concentrations.
Target Information
The NFκB transcription factor was originally identified as a protein complex consisting of a DNA-binding subunit and an associated protein.
The DNA-binding subunit is functionally related to c-Rel p75 and RelB p68. The p50 subunit was initially believed to be a unique protein derived from the amino-terminus of a precursor designated p105.
A second protein designated p52 (previously referred to as p49) has been identified that can act as an alternative NFκB subunit.
RelB does not bind with high affinity to NFκB sites, but heterodimers between RelB and p50 bind with an affinity comparable to that of p50 NFκB homodimers.
However, RelB/p50 heterodimers, in contrast to NFκB heterodimers, transactivate transcription of promoters containing κB binding sites.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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