Thermo Fisher Scientific Caspase 1 Polyclonal Antibody
Human Caspase-1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 3 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues within the p20 subunit of human caspase-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 125 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10987516 |
Product Specific Information
PA5-17570 detects Caspase 1 in Western Blot (WB) application with human samples.
It is not recommended to aliquot this antibody.
Target Information
Caspases are a family of cysteine proteases divided into apoptotic and inflammatory subfamilies.
Unlike apoptotic caspases, inflammatory caspases are associated with immune responses to microbial pathogens rather than cell death.
Members include caspase-1, -4, -5, and -12, which activate proinflammatory cytokines such as IL-1β and IL-18.
Caspase-1, initially identified as an IL-1β-converting enzyme, was later found to be a mammalian homolog of the C. elegans cell death gene ced-3, whose overexpression can induce apoptosis in fibroblasts.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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