Thermo Fisher Scientific Human BRSK1 Synthetic Peptide
인간 BRSK1 단백질의 C-말단 28개 아미노산 서열을 기반으로 한 합성 펩타이드. 항체 PA5-20352의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태로 제공되며, PBS(pH 7.2, 0.1% BSA) 용액에 보관. 연구용으로만 사용.
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 28 amino acids near the carboxy terminus of human BRSK1.
PEP-0472 can be used as a blocking peptide with polyclonal antibody PA5-20352.
Target Information
BRSK1 (SAD1) is a serine/threonine kinase and a UV-induced DNA damage checkpoint kinase. It is ubiquitously expressed, with highest levels in the brain and testes. Similar to its yeast homolog, BRSK1 is involved in stress-induced cell cycle arrest. Overexpression leads to G2/M arrest in HeLa S2 cells, while reduced expression via siRNA partially abrogates UV-induced G2/M arrest, indicating its role in DNA damage checkpoint function.
BRSK1 and BRSK2 are required for mammalian neuronal polarization. While single mutants are viable, double-mutant mice die shortly after birth, showing neurons with uniformly sized neurites expressing both axonal and dendritic markers. At least two isoforms of BRSK1 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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