Thermo Fisher Scientific Human BRSK1 Synthetic Peptide
인간 BRSK1 단백질의 중심부 28개 아미노산 서열을 기반으로 한 합성 펩타이드입니다. 항체 PA5-20353의 블로킹 펩타이드로 사용 가능하며, 순수 정제된 액상 형태로 제공됩니다. 연구용으로 DNA 손상 체크포인트 및 신경세포 극성 연구에 활용됩니다.
- 카탈로그번호
- PEP0473
- 카테고리
- Esters
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Human BRSK1 Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 28 amino acids near the center of human BRSK1.
PEP-0473 can be used as a blocking peptide with polyclonal antibody PA5-20353.
Target Information
BRSK1 (SAD1) is a serine/threonine kinase and a UV-induced DNA damage checkpoint kinase.
It is ubiquitously expressed, with highest levels in the brain and testes.
Similar to its yeast homolog, BRSK1 is involved in stress-induced cell cycle arrest.
Overexpression leads to G2/M arrest in HeLa S2 cells, and UV-induced G2/M arrest can be partially abrogated by reduced BRSK1 expression via siRNA, indicating its role in DNA damage checkpoint function.
Both BRSK1 and BRSK2 are required for mammalian neuronal polarization.
Double-mutant mice lacking both genes die within two hours of birth, and their neurons show uniformly sized neurites with both axonal and dendritic markers.
At least two isoforms of BRSK1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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