Thermo Fisher Scientific Human p53AIP1 Synthetic Peptide

Thermo Fisher Scientific Human p53AIP1 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of human p53AIP1.
PEP-0475 can be used as a blocking peptide with polyclonal antibody PA5-20355.

Target Information

The novel protein p53AIP1 (p53-regulated apoptosis-inducing protein 1) has been identified from direct cloning of p53 binding sequences from human genomic DNA.
Expression of p53AIP1 in mitochondria is induced by wild-type p53, leading to apoptotic cell death through dissipation of mitochondrial potential.
Severe DNA damage causes phosphorylation of p53 at Ser-46, activation of p53AIP1 expression, and apoptotic cell death.
DNA damage-inducible apoptotic cell death is enhanced through transcriptional activation of p53AIP1.
p53R2 is directly regulated by p53 for supplying nucleotides to repair damaged DNA, playing a pivotal role in cell survival. Dysfunction of this pathway may result in activation of p53-dependent apoptosis to eliminate dangerous cells.
Conversely, p53AIP1 plays an important role in mediating p53-dependent apoptosis, and phosphorylation of Ser46 regulates transcriptional activation of this apoptosis-inducing gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.