Thermo Fisher Scientific Human STK29 Synthetic Peptide
인간 BRSK2 단백질의 C-말단 23개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20358의 블로킹 펩타이드로 사용 가능하며, 정제된 액상 형태로 제공됩니다. 연구용으로만 사용되며, -20°C에서 보관합니다.
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Thermo Fisher Scientific Human STK29 Synthetic Peptide
Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% Sodium Azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 23 amino acids near the carboxy terminus of human BRSK2.
PEP-0478 can be used as a blocking peptide with polyclonal antibody PA5-20358.
Target Information
BRSK2 is a brain-selective serine/threonine kinase 2 mainly expressed in the brain, with weaker expression in testis and pancreas.
BRSK2 expressed in insect cells specifically phosphorylates WEE1A, CDC25C, and CDC25B in an in vitro assay.
DNA damage induced by ultraviolet (UV) irradiation or methyl methane sulfonate, but not by ionizing radiation, enhances endogenous BRSK2 kinase activity in a caffeine-sensitive manner and causes translocation of BRSK2 from the cytoplasm to the nucleus.
Overexpression of BRSK2 in HeLa cells results in increased phosphorylation of CDC25C and induces G2/M arrest.
Small interfering RNA against BRSK2 partly abrogates UV-induced G2/M arrest, suggesting BRSK2 may act as a checkpoint kinase upon DNA damage induced by UV irradiation or methyl methane sulfonate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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