Thermo Fisher Scientific BSEP Polyclonal Antibody
BSEP 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody. Western blot 및 IHC(P)에서 검증됨. Human 및 Mouse 반응성. 고순도 액상 형태로 제공되며 장기 보관 시 -20°C 권장. 연구용으로만 사용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:100
- Publications: View reference
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 1038–1067 amino acids from the C-terminal region of human ABCB11 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2220680 |
Target Information
ABCB11 is involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. It is expressed predominantly in the liver, localized to the canalicular microvilli and subcanalicular vesicles of hepatocytes. Structurally, ABCB11 is a multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP-binding cassette (ABC) domain.
Defects in ABCB11 cause progressive familial intrahepatic cholestasis 2 (PFIC2), an inherited liver disease of childhood characterized by cholestasis and normal serum gamma-glutamyltransferase activity. Mutations are also found in chronic intrahepatic cholestasis without a familial history of liver disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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