Thermo Fisher Scientific Phospho-SMAD2 (Ser118) Polyclonal Antibody
Phospho-SMAD2 (Ser118) 특이적 토끼 폴리클로날 항체로, TGF-β 신호전달 연구에 적합합니다. ICC/IF 및 Dot blot에 사용 가능하며, 다양한 종에서 교차 반응이 예측됩니다. Protein A 및 항원 친화 정제, 0.5 mg/mL 농도, PBS buffer에 보관됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 5 µg/mL |
| Dot blot (DB) | 1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S118 of human SMAD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2193055 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, canine, mouse, porcine, rat, and zebrafish based on sequence homology.
Target Information
SMAD2 (MADH2, MAD2) regulates multiple cellular processes such as cell proliferation, apoptosis, and differentiation. It interacts with TGF-beta receptors through the SMAD anchor for receptor activation, playing a central role in TGF-beta signaling. Phosphorylation of SMAD2 enhances its transcriptional activity and regulates its nuclear translocation with SMAD4, forming transcriptional repressor complexes. SMAD2 can also mediate activin signaling and exists in alternatively spliced transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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