Thermo Fisher Scientific Phospho-TPPP (Ser18) Polyclonal Antibody
TPPP 단백질의 Ser18 인산화 형태를 인식하는 토끼 폴리클로날 항체. Western blot 및 IHC(P) 검증 완료. 인간, 마우스, 랫트 반응성. 1 mg/mL 액상 형태, PBS/glycerol buffer 보존. 연구용으로만 사용 가능.
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TPPP (Accession O94811), corresponding to amino acid residues around phosphorylated Ser18. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2817450 |
Product Specific Information
This antibody detects endogenous levels of TPPP only when phosphorylated at Ser18.
Target Information
Tubulin family members are globular proteins important in the assembly of microtubules, which are structural components playing key roles in mitosis, cytokinesis, and vesicle transport.
TPPP (Tubulin polymerization-promoting protein), also known as p24 or p25, is a 219 amino acid protein localized in the perinuclear region of the cytoplasm. It can form dimers and promotes tubulin polymerization into double-walled tubules or stabilized aggregates. Overexpression of TPPP interferes with mitotic spindle formation and nuclear envelope breakdown.
TPPP is phosphorylated by TPK II and encoded by a gene located on human chromosome 5. It may play roles in microtubule polymerization, bundling, stabilization, and maintenance of the microtubule network integrity, as well as in mitotic spindle assembly and nuclear envelope breakdown.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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