Thermo Fisher Scientific Phospho-Torc2 (Ser171) Polyclonal Antibody
TORC2 단백질의 Ser171 인산화 형태를 특이적으로 인식하는 Rabbit Polyclonal 항체. Western blot 및 IHC(Paraffin) 분석에 적합. Human, Mouse, Rat 반응성. PBS/glycerol 완충액에 보관하며 -20°C에서 저장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CRTC2 (Accession Q53ET0), corresponding to amino acid residues around phosphorylated Ser171. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2817449 |
Product Specific Information
This antibody detects endogenous levels of TORC2 only when phosphorylated at Ser171.
Target Information
CRTC2, also known as TORC2 (Transducers Of Regulated cAMP Response Element-Binding (CREB) 2), and the related protein CRTC1 are potent CREB coactivators exported from the nucleus in a CRM1-dependent manner via phosphorylation-dependent interactions. Phosphorylation and nuclear/cytoplasmic shuttling play an important role in regulating gluconeogenesis by cAMP. CRTC2 is expressed in B and T lymphocytes and abundantly in the thymus, regulating genes involved in cellular energy metabolism, while CRTC1 is essential for energy balance and fertility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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